A plethora of epidermal growth factor–like proteins in polycystic kidneys
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چکیده
منابع مشابه
Erythropoietin in polycystic kidneys.
Erythropoietin (EPO) formation in kidneys of 18 patients with autosomal dominant polycystic kidney disease (ADPKD) was investigated. In 12 patients on hemodialysis and in 6 patients with preterminal renal failure serum, EPO was 29 +/- 7 and 16 +/- 1.5 mU/ml and hemoglobin concentrations were 11.0 +/- 0.6 and 12.7 +/- 1.2 g/dl, respectively. Cyst fluid from a total of 357 renal cysts was obtaine...
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BACKGROUND While the genetic basis of autosomal dominant polycystic kidney disease (ADPKD) has been clearly established, the pathogenesis of renal failure in ADPKD remains elusive. Cyst formation originates from proliferating renal tubular epithelial cells that de-differentiate. Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increa...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2004
ISSN: 0085-2538
DOI: 10.1111/j.1523-1755.2004.00667.x